Vitamin D Receptor Contents and Receptor Expresslon Rates of Cd4+ and Cd8+ T Lymphocytes Ln Renal Transplant Reclplents

This study aims to evaluate the vitamin D receptor (VDR) expression and intracellular amounts of VDRs in CD4+ CD8+ lymphocytes renal transplant (RT) recipients with chronic allograft dysfunction (CAD). A total 43 patients (Group 1:RT patients=29 patients, 15 CAD proven by biopsy 1a), 14 stable function 1b), Group 2:Control group=14 healthy individuals) have been enrolled this study. 25-hydroxycholecalciferol, 1.25 dihydroxycholecalciferol levels were measured. The number cells expressing VDR among type T subjects was determined as % those cell groups. mean molecule contents per measured expressed fluorescence intensities (MFI). No difference found between 1 2 terms their levels, percentages (p>0.05). CD4+/VDR(MFI) CD8+/VDR(MFI) values higher RT than (p<0.001). When patient subgroups compared, there no statistically significant differences regarding CD4+/VDR(%), CD8+/VDR(%), showed who had did not change, but content increased due reasons independent serum 25-hydroxycholecalciferol levels.